Profil Adenokarsinoma Kolon di RSUP Prof Dr. R. D. Kandou dan Siloam Hospitals Periode Januari – Juni Pemberian Kombinasi 5FU-Leucovorin dengan Phaleria macrocarpa terhadap Proliferasi Sel dan Diameter Adenokarsinoma Kolon Tikus Sprague dawley. PROPOLIS TERHADAP KSPRESI PROTEIN CASPASE 8, APOPTOSIS, DAN PROLIFERASI PADA KULTUR SEL ADENOKARSINOMA KOLON (WiDr).

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Has activity as single agent that inhibits DNA replication and transcription. Mekanisme anti kanker propolis melalui induksi apoptosis dan juga melalui penghambatan proliferasi dalam siklus sel. Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin. Fulda S, Debatin KM. Immunomodulatory Action of Propolis on Macrophage Activation.

It does not have a role in the adjuvant setting, and in metastatic settings, it is limited to palliative therapy for selected metastatic sites such as bone or brain metastases.

Irinotecan Camptosar, CPT Semisynthetic derivative of camptothecin, an alkaloid extract from theCamptotheca acuminate tree. It is indicated for metastatic colorectal cancer in patients who have been previously treated with fluoropyrimidine- oxaliplatin- and irinotecan- based chemotherapy; an anti-VEGF therapy eg, bevacizumab, ziv-aflibercept ; and, if KRAS wild type, an anti-EGFR therapy eg, cetuximab, panitumumab.

Penelitian ini merupakan penelitian experimental laboratories, post test with control group design. User Username Password Remember me. Bevacizumab Avastin Murine derived monoclonal antibody that inhibits angiogenesis by targeting and inhibiting vascular endothelial growth factor VEGF.

In addition to 5-fluorouracil, oral fluoropyrimidines such as capecitabine Xeloda and tegafur are increasingly used as monotherapy or in combination with oxaliplatin Eloxatin and irinotecan Camptosar. View full drug information Capecitabine Xeloda Fluoropyrimidine carbamate prodrug from of 5-fluorouracil 5-FU. Wang X dan Zhang Y.

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Tumor kolon diperoleh dengan induksi 1,2-DMH subkutan. Insidensi kanker kolon di seluruh dunia masih tinggi dan menjadi penyebab kematian terbanyak kategori penyakit tidak menular. National Comprehensive Cancer Network, Inc. The addition of anti-EGFR antibody treatment to standard chemotherapy regimens for patients with advanced colorectal cancer improves progression-free survival for those with wild-type but not mutant KRAS status.

Allows for purine and pyrimidine synthesis, both of which are needed for normal erythropoiesis. A Medicine the Legacy of the Gods.

Cancer Incidence and Mortality Worldwide: The authors concluded that adjuvant chemotherapy provides significant disease-free survival benefit because it reduces the recurrence rate particularly within the first 2 years of adenokqrsinoma therapy but with some benefit in years Regorafenib Stivargaa kinase inhibitor, was approved in September Statistically significant benefit in overall survival and progression- free survival was observed for regorafenib over placebo in patients with mCRC in whom all approved standard therapies have failed.

Shown to be effective in adjuvant setting. Food Jolon Toxicol, Indicated in combination with 5-fluorouracil, leucovorin, irinotecan FOLFIRI for metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin regimen.

Jurnal e-CliniC (eCl)

Targeting mTOR network in colorectal cancer therapy. Surat Data Diri Penulis. Proliferasi sel dinilai dengan pengecatan IHC Ki sedangkan diameter massa tumor diukur menggunakan caliper tumor.

User Username Password Remember me. Cytotoxicity is cell-cycle nonspecific with activity in all phases of the cell cycle. Newer, more selective ways of administering radiation therapy such as stereotactic radiotherapy CyberKnife and tomotherapy are currently being investigated and may extend indications for radiotherapy in the management of colon cancer in the future. Pembedahan tetap merupakan pilihan utama dengan modalitas lainnya berupa adenokarsinomx, radiasi dan imunoterapi seperti P.

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC. Natural Product Communications, 5 1: CA Cancer J Clin, 55 3: Converted by the carboxylesterase enzyme to its active metabolite from, SN Inactive in its parent form. They also examined the adenokarsinona of the KRAS mutation status.

Perpustakaan Unika Atma Jaya

Masters thesis, Master of Biomedical Science. Redox Reactivity in Propolis: Also indicated for previously untreated advanced colorectal cancer in combination with 5-FU and leucovorin. Undergoes hydrolysis in liver and tissues to form the active moiety fluorouracilinhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to th Leucovorin Folinic acid, Citrovorum Factor Reduced form of folic acid that does not require enzymatic reduction reaction for activation.

Asian Pacific Journal Cancer Preventions, 7; p. Boerl on Human Cancer Cell Lines. Life Sci, 68 8: Abstract Insidensi kanker kolon di seluruh dunia masih tinggi dan menjadi penyebab kematian terbanyak kategori penyakit tidak menular.